Novel Approaches For Colon Site-Specific Drug Delivery: An Overview Of Recent Advancements
نویسندگان
چکیده
Nowadays, various routes of administration have been explored for the effective delivery drug to target site. The oral route is considered be most convenient drugs patients. But it has a serious drawback in conditions where localized colon required. colon-targeted system (CDDS) potential approach systemic and topical treating inflammatory bowel diseases such as ulcerative colitis, Crohn’s disease, cancer, amoebiasis. CDDS would provide direct treatment at site reduced dose, adverse effects. should able release into colon, indicating that neither nor absorption take place stomach or small intestine, bioactive agent degraded there. Instead, only released absorbed when reaches colon. both local delivery. This review mainly compares primary approaches (Colon Specific Drug Delivery) namely prodrugs, pH time-dependent systems, microbially triggered which achieved limited success had limitations compared with newer pressure-controlled colonic capsules, CODESTM, osmotic controlled systems. also focused on possible benefits issues associated novel system. Recent advancements designing systems their pharmaceutical applications are covered particular emphasis formulation technologies.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s08.575